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KMID : 0360220120530030385
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Journal of the Korean Ophthalmological Society
2012 Volume.53 No. 3 p.385 ~ p.389
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Risk Factors of Graft Failure in Post-Keratoplasty Ocular Hypertension
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Joo Jong-Soo
Lee You-Kyung
Joo Choun-Ki
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Abstract
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Purpose: To assess the risk factors proceeding to graft failure in post-keratoplasty ocular hypertension patients.
Methods: In 35 eyes diagnosed with post-keratoplasty ocular hypertension (graft failure: 13 eyes; graft survival: 22 eyes), relationships between graft status at the observation time and pre-keratoplasty diagnosis, lens status, history of graft failure, donor size, difference between donor and recipient graft size, donor corneal endothelial cell count, post-keratoplasty intraocular pressure (after 1 week and maintenance intraocular pressure after surgery), and number of antiglaucomatic agents were investigated. The relative risks of each factor to induce graft failure were also evaluated.
Results: Previous graft failure history, pre-existing pseudophakic bullous keratopathy and aphakia/pseudophakia showed statistically significant high probabilities of proceeding to graft failure (p < 0.05). In particular, the intraocular pressure 1 week after the graft was statistically higher (p < 0.05) in the graft failure group (24.31 ± 8.82 mm Hg) than in the graft survival group (16.81 ± 6.69 mm Hg).
Conclusions: Strict management of intraocular pressure in the early phase of penetrating keratoplasty could contribute to reducing graft failure in post-keratoplasty ocular hypertension patients.
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KEYWORD
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Graft failure, Penetrating keratoplasty, Post-keratoplasty ocular hypertension
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